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apalutamide will minimize the extent or result of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with medications that are CYP3A4 substrates may result in decreased publicity to these prescription drugs.Modafinil could possibly be routine-f